Data/hora: 11/06/2024 11:16:59

Provedor de dados: | 42
País: | Brazil
Título: | Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives
Autores: | PINHEIRO,LUIZ C.S.; FEITOSA,LÍVIA M.; SILVEIRA,FLÁVIA F. DA; BOECHAT,NUBIA.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | Malaria; Plasmodium falciparum; Artemisinin; Hybrid.
Resumo: | ABSTRACT According to the World Health Organization, malaria remains one of the biggest public health problems in the world. The development of resistance is a current concern, mainly because the number of safe drugs for this disease is limited. Artemisinin-based combination therapy is recommended by the World Health Organization to prevent or delay the onset of resistance. Thus, the need to obtain new drugs makes artemisinin the most widely used scaffold to obtain synthetic compounds. This review describes the drugs based on artemisinin and its derivatives, including hybrid derivatives and dimers, trimers and tetramers that contain an endoperoxide bridge. This class of compounds is of extreme importance for the discovery of new drugs to treat malaria.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301251
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201820170830
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.90 n.1 suppl.2 2018
Fonte: | info:eu-repo/semantics/openAccess