Data/hora: 01/06/2024 02:47:15

Provedor de dados: | 42
País: | Brazil
Título: | Differential Effect of Solution Conditions on the Conformation of the Actinoporins Sticholysin II and Equinatoxin II
Autores: | FAUTH,EDSON V.F.; CILLI,EDUARDO M.; LIGABUE-BRAUN,RODRIGO; VERLI,HUGO.
Data: | 2014-12-01
Ano: | 2014
Palavras-chave: | Actinoporins; GROMACS; Molecular dynamics; Pore-forming proteins.
Resumo: | Actinoporins are a family of pore-forming proteins with hemolytic activity. The structural basis for such activity appears to depend on their correct folding. Such folding encompasses a phosphocholine binding site, a tryptophan-rich region and the activity-related N-terminus segment. Additionally, different solution conditions are known to be able to influence the pore formation by actinoporins, as for Sticholysin II (StnII) and Equinatoxin II (EqtxII). In this context, the current work intends to characterize the influence of distinct solution conditions in the conformational behavior of these proteins through molecular dynamics (MD) simulations. The obtained data offer structural insights into actinoporins dynamics in solution, characterizing its conformational behavior at the atomic level, in accordance with previous experimental data on StnII and EqtxII hemolytic activities.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401949
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201420140270
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.86 n.4 2014
Fonte: | info:eu-repo/semantics/openAccess