Data/hora: 07/06/2024 02:18:19

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Intra-uterine experimental infection by Ureaplasma diversum induces TNF-α mediated womb inflammation in mice	
Autores: 	Silva,Jamile R.; Ferreira,Lício F.A.A.; Oliveira,Percíllia V.S.; Nunes,Ivanéia V.; Pereira,Ítalo S.; Timenetsky,Jorge; Marques,Lucas M.; Figueiredo,Tiana B.; Silva,Robson A.A.	
Data: 	2016-01-01	
Ano: 	2016	
Palavras-chave: 	Mycoplasma; Uterus; Ureaplasma; Mice.	
Resumo: 	Ureaplasma diversum is an opportunistic pathogen associated with uterine inflammation, impaired embryo implantation, infertility, abortions, premature birth of calves and neonatal pneumonia in cattle. It has been suggested that the intra-uterine infection by Ureaplasma diversum can cause vascular changes that hinder the success of pregnancy. Thus, the aim of this study was to evaluate the changes of intrauterine site of A/J mice in estrus or proestrus phase inoculated with Ureaplasma diversum. The infection was monitored at 24, 48 and 72 hours by the PCR methodology to detect the Ureaplasma in the inoculation site and the profile of circulating blood cells. Morphological changes, intensity of inflammation and the production of cytokines were compared. The infected mice showed local inflammation through the production of IFN-γ and TNF-α. Ureaplasma diversum infections in the reproductive tract of studied mice seemed to be associated with the production of pro-inflammatory cytokines in uterine parenchyma. The levels of TNF-α of infected mice were dependent on the bacterial load of inoculated Ureaplasma. Uterine experimental infections by Ureaplasma diversum have not been mentioned yet and herein we presented the first report of an intrauterine infection model in mice.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000200643	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201620150244	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.88 suppl.1 2016	
Fonte: 	info:eu-repo/semantics/openAccess