Data/hora: 09/06/2024 19:13:02

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Sensitive and rapid titrimetric and spectrophotometric methods for the determination of stavudine in pharmaceuticals using bromate-bromide and three dyes	
Autores: 	Basavaiah,Kanakapura; Ramakrishna,Veeraiah; Somashekar,Chikkaswamy; Kumar,Urdigere R. Anil.	
Data: 	2008-06-01	
Ano: 	2008	
Palavras-chave: 	Stavudine determination; Titrimetry; Spectrophotometry; Bromate-bromide; Dyes; Pharmaceuticals.	
Resumo: 	Four sensitive and rapid methods for the determination of stavudine (STV) in bulk drug and in dosage forms were developed and optimized. In titrimetry, aqueous solution of STV was treated with a known excess of bromate-bromide in HCl medium followed by estimation of unreacted bromine by iodometric back titration. Spectrophotometric methods involve the addition of a measured excess of bromate-bromide in HCl medium and subsequent estimation of the residual bromine by reacting with a fixed amount of methyl orange, indigocarmine or thymol blue followed by measurement of absorbance at 520 nm (method A), 610 nm (method B) or 550 nm (method C). In all the methods, the amount of bromate reacted corresponds to the amount of STV. Calculations in titrimetry were based on a 1:0.666 (STV:KBrO3) stoichiometry and the method was found to be applicable over 3.5-10 mg range. A linear increase in absorbance with concentration of STV was observed in the spectrophotometric methods, and the Beer's law was obeyed over the concentration ranges 0.125-1.75, 1-10 and 1-9.0 µg mL-1 STV for method A, method B and method C, respectively. The methods when applied to the determination of STV in tablets and capsules were found to give satisfactory results.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000200003	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/S0001-37652008000200003	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.80 n.2 2008	
Fonte: 	info:eu-repo/semantics/openAccess