Data/hora: 11/06/2024 07:28:03

Provedor de dados: | 42
País: | Brazil
Título: | Silver and gold nanoparticles from tannic acid: synthesis, characterization and evaluation of antileishmanial and cytotoxic activities
Autores: | LOPES,LOURDES C.S.; BRITO,LUCAS M.; BEZERRA,THAYLLAN T.; GOMES,KLEYTON N.; CARVALHO,FERNANDO A. DE A.; CHAVES,MARIANA HELENA; CANTANHÊDE,WELTER.
Data: | 2018-09-01
Ano: | 2018
Palavras-chave: | Green synthesis; Leishmaniasis; Metallic nanoparticles; Tannic acid.
Resumo: | Abstract Gold (Au0) and silver (Ag0) nanoparticles were synthesized using tannic acid (TA) as both reducing and stabilizer. Nanoparticles formation, stability, and interaction with TA were compared to citrate-coated nanoparticles and monitored by UV-Vis, zeta potential, and transmission electron microscopy. TA coating resulted in a red-shift and broadening of bands compared to citrate-coated nanoparticles (NPs-Cit). AgNPs-TA and AuNPs-TA are negatively charged with mean surface charge of -29.4 mV and -29.6 mV, respectively. TEM images showed polydispersety of AuNPs-TA (6-42 nm) and aggregation of AgNPs-TA (12-71 nm). In vitro assays of Leishmania amazonensis promastigotes showed an increment of antileishmanial activity for AgNPs-TA in relation to AgNPs-Cit, while AuNPs-TA and AuNPs-Cit did not affect the protozoas at tested concentrations. CC50 value for AgNPs-TA suggested that TA attenuates nanosilver toxicity comparatively to its precursor (Ag+). This investigation can contribute to the development of new, green, and fast produced drugs aiming at leishmaniasis treatment.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000602679
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201820170598
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.90 n.3 2018
Fonte: | info:eu-repo/semantics/openAccess