Data/hora: 11/06/2024 03:19:41

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Chemical Constituents and Pharmacology properties of Aristolochia triangularis: a south brazilian highly-consumed botanical with multiple bioactivities	
Autores: 	OLIVEIRA,SIMONE Q.; KRATZ,JADEL M.; CHAVES,VITOR C.; GUIMARÃES,TATIANA R.; COSTA,DANIELLE T.M.; DIMITRAKOUDI,SAPFO; VONTZALIDOU,ARGYRO; BORDIGNON,SÉRGIO A.L.; SIMIONATO,CESAR P.; STEINDEL,MÁRIO; REGINATTO,FLÁVIO H.; SIMÕES,CLÁUDIA M.O.; SCHENKEL,ELOIR P.	
Data: 	2019-01-01	
Ano: 	2019	
Palavras-chave: 	Aristolochia triangularis; Antiproliferative; Antiherpes; Antimicrobial; Antiprotozoal; Aristolochic acids.	
Resumo: 	Abstract: Aristolochia triangularis Cham., is one of the most frequently used medicinal plant in Southern Brazil. Preparations containing the leaves and/or stems are traditionally used as anti-inflammatory, diuretic, as well as antidote against snakebites. This study screened A. triangularis extracts, fractions and isolated compounds for different bioactivities. A weak antiproliferative activity against human lung cancer cell line (A549) was observed only for chloroform fraction obtained from stems (CFstems - CC50: 2.93 µg/mL). Also, a moderate antimicrobial activity against Staphylococcus aureus was detected just for chloroform fraction obtained from leaves (CFleaves -13-16 mm inhibition zone). Additionally, two semi-purified fractions (CFstems-4 and CFleaves-4) selectively inhibited HSV-1 replication (IC50 values of 0.40 and 2.61 µg/mL, respectively), while only CFleaves showed promising results against Leishmania amazonensis. Fractionation of extracts resulted in the isolation of one neolignan (-) cubebin and one lignan (+) galbacin. However, these compounds are not responsible for the in vitro bioactivities herein detected. The presence of aristolochic acid I and aristolochic acid II in the crude ethanol extract of stems (CEEstems) and leaves (CEEleaves) was also investigated. The HPLC analysis of these extracts did not display any peak with retention time or UV spectra comparable to aristolochic acids I and II.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500801	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201920180621	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.91 n.3 2019	
Fonte: 	info:eu-repo/semantics/openAccess