Data/hora: 07/06/2024 03:39:02

Provedor de dados: | 42
País: | Brazil
Título: | Antioxidant, hemolytic, antimicrobial, and cytotoxic activities of the tropical Atlantic marine zoanthid Palythoa caribaeorum
Autores: | ALENCAR,DANIEL B.; MELO,ARTHUR A.; SILVA,GISELLE C.; LIMA,REBECA L.; PIRES-CAVALCANTE,KELMA M.S.; CARNEIRO,RÔMULO F.; RABELO,ADRIANA S.; SOUSA,OSCARINA V.; VIEIRA,REGINE H.S.F.; VIANA,FRANCISCO A.; SAMPAIO,ALEXANDRE H.; SAKER-SAMPAIO,SILVANA.
Data: | 2015-06-01
Ano: | 2015
Palavras-chave: | Biological activity; Marine invertebrate; Natural product; Sphenopidae.
Resumo: | Marine invertebrates are capable of synthesizing bioactive compounds, which may be beneficial to human health. The aim of this study was to evaluate the antioxidant, hemolytic, antimicrobial and cytotoxic activities of crude extract (70% EtOH), and dichloromethane (DCM), ethyl acetate (EtOAc), and aqueous (Aq) fractions of the marine zoanthid Palythoa caribaeorum. The phenolic compound contents of the crude extract, DCM, EtOAc and Aq fractions were 12.33, 18.17, 10.53, and 3.18 mg GAE per gram, respectively. DPPH radical scavenging activity showed slight variation. IC50 of crude extract, DCM, EtOAc and Aq fractions were 11.13, 11.25, 11.74, and 11.28 µg mL-1, respectively. Among the sample, ferrous ion chelating was the highest in crude extract (IC50 302.90 µg mL-1), followed by EtOAc, Aq, and DCM fractions with 457.77, 547.91, and 641.82 µg mL-1, respectively. Ferric-reducing antioxidant power showed optical density at about 0.5. The samples tested exhibited low hemolytic activity under 10% up to a concentration of 50 μg mL-1. No antimicrobial activity was observed against any of the tested bacterial strains. For the cytotoxic activity, LC50 of DCM, crude extract, EtOAc, and Aq were 52.10, 83.06, 86.34, and 117.45 μg mL-1, showing high toxicity.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201113
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201520140370
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.87 n.2 2015
Fonte: | info:eu-repo/semantics/openAccess