Data/hora: 06/06/2024 01:09:54

Provedor de dados: | 42
País: | Brazil
Título: | Non-coding RNAs in schistosomes: an unexplored world
Autores: | Oliveira,Katia C; Carvalho,Mariana L. P; Maracaja-Coutinho,Vinicius; Kitajima,João P; Verjovski-Almeida,Sergio.
Data: | 2011-06-01
Ano: | 2011
Palavras-chave: | Schistosoma mansoni; Non-coding RNAs; Gene expression profile; Genome; Transcriptome.
Resumo: | Non-coding RNAs (ncRNAs) were recently given much higher attention due to technical advances in sequencing which expanded the characterization of transcriptomes in different organisms. ncRNAs have different lengths (22 nt to &gt;1, 000 nt) and mechanisms of action that essentially comprise a sophisticated gene expression regulation network. Recent publication of schistosome genomes and transcriptomes has increased the description and characterization of a large number of parasite genes. Here we review the number of predicted genes and the coverage of genomic bases in face of the public ESTs dataset available, including a critical appraisal of the evidence and characterization of ncRNAs in schistosomes. We show expression data for ncRNAs in Schistosoma mansoni. We analyze three different microarray experiment datasets: (1) adult worms' large-scale expression measurements; (2) differentially expressed S. mansoni genes regulated by a human cytokine (TNF-α) in a parasite culture; and (3) a stage-specific expression of ncRNAs. All these data point to ncRNAs involved in different biological processes and physiological responses that suggest functionality of these new players in the parasite's biology. Exploring this world is a challenge for the scientists under a new molecular perspective of host-parasite interactions and parasite development.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000200026
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652011000200026
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.83 n.2 2011
Fonte: | info:eu-repo/semantics/openAccess