Data/hora: 11/06/2024 08:00:08

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Melipona mondury produces a geopropolis with antioxidant, antibacterial and antiproliferative activities	
Autores: 	SANTOS,TÁSSIA L.A. DOS; QUEIROZ,RAPHAEL F.; SAWAYA,ALEXANDRA C.H.F.; LOPEZ,BEGOÑA GIMENEZ-CASSINA; SOARES,MILENA B.P.; BEZERRA,DANIEL P.; RODRIGUES,ANA CAROLINA B.C.; PAULA,VANDERLÚCIA F. DE; WALDSCHMIDT,ANA MARIA.	
Data: 	2017-01-01	
Ano: 	2017	
Palavras-chave: 	Antibacterial; Antioxidant; Antiproliferative; Geopropolis; Melipona mondury.	
Resumo: 	ABSTRACT Geopropolis is a special type of propolis produced by stingless bees. Several pharmacological properties have been described for different types of geopropolis, but there have been no previous studies of the geopropolis from Melipona mondury. In this study, we investigated the antioxidant, antibacterial, and antiproliferative activities of M. mondury geopropolis, and determined its chemical profile. The antioxidant activity was determined using in vitro ABTS·+, ·DPPH, and β-carotene/linoleic acid co-oxidation methods. The antibacterial activity was determined using a microdilution method with Pseudomonas aeruginosa, Staphylococcus aureus, and methicillin-resistant S. aureus. The antiproliferative effect was determined in tumor cell lines using the Alamar Blue assay. The chemical profile was obtained using UHPLC-MS and UHPLC-MS/MS. The butanolic fraction had the highest concentration of phenolic compounds and more potent antioxidant properties in all assays. This fraction also had bacteriostatic and bactericidal effects against all bacterial strains at low concentrations, especially S. aureus. The hexane fraction had the highest antiproliferative potential, with IC50 values ranging from 24.2 to 46.6 µg/mL in HL-60 (human promyelocytic leukemia cell) and K562 (human chronic myelocytic leukemia cell), respectively. Preliminary chemical analysis indicates the presence of terpenes and gallic acid in the geopropolis. Our results indicate the therapeutic potential of geopropolis from M. mondury against inflammatory, oxidative, infectious, and neoplastic diseases.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000502247	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201720160725	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.89 n.3 suppl.0 2017	
Fonte: 	info:eu-repo/semantics/openAccess