Data/hora: 05/06/2024 18:13:18

Provedor de dados: | 42
País: | Brazil
Título: | Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testing
Autores: | LUCINDA,LEDA M.F.; AARESTRUP,BEATRIZ J.V.; REBOREDO,MAYCON M.; PAINS,THAIS D.A.; CHAVES,RAPHAEL Z.; REIS,JOÃO E.P.; LOUZADA,MÁRIO J.Q.; GUERRA,MARTHA O.
Data: | 2017-12-01
Ano: | 2017
Palavras-chave: | Bone density; DEXA scan; Ginkgo biloba; Osteoporosis.
Resumo: | ABSTRACT Evaluate the effect of the extract of Ginkgo biloba in the bone alkaline phosphatase, bone mineral density, in the mechanical properties of the tibia in rats with glucocorticoid-induced-osteoporosis. After osteoporosis induction, the rats were divided into five groups: Osteoporosis; EGb1 (28 mg/Kg); EGb2 (56 mg/Kg); alendronate (0.2 mg/animal) and control. The animals were treated during 20 and 30 days. The control group was compared with the osteoporosis’s (Student’s t-test), while the other were analyzed by ANOVA test followed by Tukey/Dunnett’T3 (p&lt;0.05). In the osteoporosis group the bone alkaline phosphatase, bone mineral density, the bone stiffness, the maximum load and the resilience were reduced. The bone alkaline phosphatase values increased in the EGb1 and EGb2 groups (30 days). In addition, in the EGb2 and alendronate groups (20 and 30 days) the bone mineral density increased. The extract of Ginkgo biloba restored bone alkaline phosphatase and bone mineral density using dual-energy x-ray absorptiometry.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602833
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201720160479
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.89 n.4 2017
Fonte: | info:eu-repo/semantics/openAccess