Data/hora: 02/06/2024 14:38:38

Provedor de dados: | 42
País: | Brazil
Título: | Evaluation of wound healing and antimicrobial properties of aqueous extract from Bowdichia virgilioides stem barks in mice
Autores: | AGRA,ISABELA K.R.; PIRES,LUANA L.S.; CARVALHO,PAULO S.M.; SILVA-FILHO,EURÍPEDES A.; SMANIOTTO,SALETE; BARRETO,EMILIANO.
Data: | 2013-09-01
Ano: | 2013
Palavras-chave: | Wound healing; Antimicrobial effect; Bowdichia virgilioides; Medicinal plant.
Resumo: | The decoction of the stem barks from Bowdichia virgilioides KUNTH is a folk remedy used to treat inflammatory disorders in Latin American and Brazil. In the present study, the wound healing activity of aqueous extract of the stem bark from B. virgilioides, called AEBv, was evaluated by the rate of healing by wound contraction and period of epithelization at different days post-wound using the wound excisional model. On day 9, the AEBv-treated animals exhibited significative reduction in the wound area when compared with controls. In wound infected with S. aureus, the AEBv significantly improved the wound contraction when compared to the saline-treated mice. The histological analysis showed that AEBv induced a collagen deposition, increase in the fibroblast count and few inflammatory cells than compared to saline-treated group. The expression of collagen type I was increased in the group treated with AEBv as indicated by immunohistochemical staining. In vitro, the AEBv was effective only against S. aureus but not against P. aeruginosa. Together, the results of this study demonstrate, for the first time, the healing and antimicrobiological effects of aqueous extract of the stem bark from B. virgilioides in the therapy of skin wounds.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000300945
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652013005000049
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.85 n.3 2013
Fonte: | info:eu-repo/semantics/openAccess