Data/hora: 09/06/2024 05:57:18

Provedor de dados: | 42
País: | Brazil
Título: | Current relevance of fungal and trypanosomatid glycolipids and sphingolipids: studies defining structures conspicuously absent in mammals
Autores: | Takahashi,Helio K.; Toledo,Marcos S.; Suzuki,Erika; Tagliari,Loriane; Straus,Anita H.
Data: | 2009-09-01
Ano: | 2009
Palavras-chave: | Glycosphingolipids; Glycosylinositol phosphorylceramides; Inositol phosphorylceramide; Leishmania; Membrane rafts; Pathogenic fungi.
Resumo: | Recently, glycosphingolipids have been attracting attention due to their role on biological systems as second messengers or modulators of signal transduction, affecting several events, which range from apoptosis to regulation of the cell cycle. In pathogenic fungi, glycolipids are expressed in two classes: neutral monohexosylceramides (glucosyl-or galactosylceramide) and acidic glycosylinositol phosphorylceramides (the latter class carries longer glycan chains). It is worth to mention that monohexosylceramides exhibit significant structural differences in their lipid moieties compared to their mammalian counterparts, whereas the glycosylinositol phosphorylceramides exhibit remarkable structural differences in their carbohydrate moieties in comparison to mammal glycosphingolipids counterpart. We observed that glycosylinositol phosphorylceramides are capable of promoting immune response in infected humans. In addition, inhibiting fungal glycosphingolipid biosynthetic pathways leads to an inhibition of colony formation, spore germination, cell cycle, dimorphism and hyphal growth. Other pathogens, such as trypanosomatids, also present unique glycolipids, which may have an important role for the parasite development and/or disease establishment. Regarding host-pathogen interaction, cell membrane rafts, which are enriched in sphingolipids and sterols, participate in parasite/fungal infection. In this review, it is discussed the different biological roles of (glyco) (sphingo)lipids of pathogenic/opportunistic fungi and trypanosomatids.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300012
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652009000300012
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.81 n.3 2009
Fonte: | info:eu-repo/semantics/openAccess