Data/hora: 01/06/2024 02:41:17

Provedor de dados: | 45
País: | Brazil
Título: | Holter electrocardiography in dogs showing doxorubicin-induced dilated cardiomyopathy
Autores: | Pereira Neto,G.B.; Andrade,J.N.B.; Sousa,M.G.; Camacho,A.A.
Data: | 2006-12-01
Ano: | 2006
Palavras-chave: | Dog; Doxorubicin; Eletrocardiogram; Cardiopathy.
Resumo: | Early identification of arrhythmias in dogs showing doxorubicin-induced cardiomyopathy was studied. Ten healthy dogs were assigned to groups A (n=5) and B (n=5). Dogs from group B were given doxorubicin 30mg/m² intravenously, every 21 days, until a cumulative dose of 180mg/m² or 240mg/m² was reached. Dogs from group A (used as control) were administered saline intravenously at the same group B intervals. As soon as myocardium dysfunction was observed in dogs from group B, determined by a shortening fraction below 20%, increased E-point to septal separation above 0.7cm, and increased end-systolic left ventricular volume index (61.4ml/m²), a 24-hour Holter was recorded in all dogs from both groups. There was an increase of minimum heart rate (44.6%) and mean heart rate (41.7%) in animals from group B in comparison with the control animals. Either supraventricular or ventricular arrhythmias were observed, despite group B dogs showed higher occurrence of supraventricular arrhytmias. Holter monitoring is efficient in early determination of heart rate and cardiac rhythm alterations in dogs showing doxorubicin-induced myocardial dysfunction.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352006000600010
Editor: | Universidade Federal de Minas Gerais, Escola de Veterinária
Relação: | 10.1590/S0102-09352006000600010
Formato: | text/html
Fonte: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia  v.58 n.6 2006
Fonte: | info:eu-repo/semantics/openAccess