Data/hora: 17/06/2024 21:13:49

Provedor de dados: | 45
País: | Brazil
Título: | Imunogenicidade da proteína M recombinante de Streptococcus equi subsp. equi coadministrada com um adjuvante molecular
Autores: | Maciel,L.F.; Magalhães,C.G.; Moraes,C.M.; Rosa,M.C.; Mendonça,M.; Moreira,A.N.; Dummer,L.A.; Finger,P.F.; Ferreira,M.R.A.; Leite,F.P.L.; Conceição,F.R.
Data: | 2017-10-01
Ano: | 2017
Palavras-chave: | Garrotilho; Streptococcus equi; RSeM e rLTB.
Resumo: | ABSTRACT The strangles is an infectious disease that affects horses from all ages and causes important economic losses in the equine-related business. The aim of this work was to evaluate the immunogenicity of the recombinant M protein from Streptococcus equi (rSeM) co-administered with the recombinant heat-labile enterotoxin B subunit from Escherichia coli (rLTB) in mice and horses. A total of 72 female Balb-c mice were divided into eight groups and 18 horses were divided into six groups. The animals were inoculated by intramuscular (IM) or intranasal (IN) routes with different treatments of rSeM, rLTB and/or Al(OH)3. The results obtained in both species, independent of administration routes, demonstrated that rSeM + rLTB had higher levels of specific serum immunoglobulins, however, in mucosal immunity the increase was not identified. Thus, the use of rSeM as vaccine antigen and rLTB as adjuvant can be a potential tool in the control of equine strangles.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Português
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352017000501351
Editor: | Universidade Federal de Minas Gerais, Escola de Veterinária
Relação: | 10.1590/1678-4162-9288
Formato: | text/html
Fonte: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia  v.69 n.5 2017
Fonte: | info:eu-repo/semantics/openAccess