Data/hora: 01/06/2024 01:46:02

Provedor de dados: 	45	
País: 	Brazil	
Título: 	Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits	
Autores: 	Souza,A.H.; Valadão,C.A.A.; Selegatto,M.A.; Almeida,R.M.; Macari,M.	
Data: 	2008-06-01	
Ano: 	2008	
Palavras-chave: 	LPS; Fever; DMSO; Rabbits.	
Resumo: 	The present study was designed to determine whether DMSO causes an inhibition on the development of fever in rabbits. The intravenous administration of LPS (1.5µg.kg-1 body weight) caused fever in both saline+LPS and DMSO+LPS group, but the onset and magnitude of the induced fever were significantly different. The saline+LPS group presented a prototypic biphasic fever whereas the DMSO+LPS group presented an attenuated febrile response, but it was not abolished. These results suggest that DMSO may provide a protective mechanism against pyrogen LPS, probably through the modulation of NF-kB mediated events, such as fever.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000300016	
Editor: 	Universidade Federal de Minas Gerais, Escola de Veterinária	
Relação: 	10.1590/S0102-09352008000300016	
Formato: 	text/html	
Fonte: 	Arquivo Brasileiro de Medicina Veterinária e Zootecnia  v.60 n.3 2008	
Fonte: 	info:eu-repo/semantics/openAccess