Data/hora: 17/06/2024 13:51:28

Provedor de dados: | 45
País: | Brazil
Título: | Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits
Autores: | Souza,A.H.; Valadão,C.A.A.; Selegatto,M.A.; Almeida,R.M.; Macari,M.
Data: | 2008-06-01
Ano: | 2008
Palavras-chave: | LPS; Fever; DMSO; Rabbits.
Resumo: | The present study was designed to determine whether DMSO causes an inhibition on the development of fever in rabbits. The intravenous administration of LPS (1.5µg.kg-1 body weight) caused fever in both saline+LPS and DMSO+LPS group, but the onset and magnitude of the induced fever were significantly different. The saline+LPS group presented a prototypic biphasic fever whereas the DMSO+LPS group presented an attenuated febrile response, but it was not abolished. These results suggest that DMSO may provide a protective mechanism against pyrogen LPS, probably through the modulation of NF-kB mediated events, such as fever.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000300016
Editor: | Universidade Federal de Minas Gerais, Escola de Veterinária
Relação: | 10.1590/S0102-09352008000300016
Formato: | text/html
Fonte: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia  v.60 n.3 2008
Fonte: | info:eu-repo/semantics/openAccess