Data/hora: 11/06/2024 14:41:06

Provedor de dados: 	45	
País: 	Brazil	
Título: 	Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy	
Autores: 	Valladão,M.L.; Scarpelli,K.C.; Metze,K.	
Data: 	2010-10-01	
Ano: 	2010	
Palavras-chave: 	Canine transmissible venereal tumor; Vincristine; Survival; Performance score; Quality of life.	
Resumo: 	The clinical utility of a life quality score during vincristine chemotherapy of dogs with canine transmissible venereal tumor (CTVT) was investigated using 93 tumor-bearing dogs in this prospective study. At diagnosis, clinical data and the performance status were evaluated according to a modified Karnofsky score (CKS) adapted for dogs. The animals were treated with vincristine sulphate (0.025mg/kg) at weekly intervals until the tumor had macroscopically disappeared. The time until the first adverse event and death were recorded. In a pilot study, CKS revealed a high inter-observer concordance (kappa=0.735; weighted kappa=0.835). CKS permitted a detailed monitoring of adverse effects during therapy. Cox regressions showed that low performance score and reduced body weight were independent predictive factors for death during chemotherapy. The modified Karnofsky performance score is a simple and reproducible clinical instrument, able to estimate patient outcome after treatment of CTVT.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000500010	
Editor: 	Universidade Federal de Minas Gerais, Escola de Veterinária	
Relação: 	10.1590/S0102-09352010000500010	
Formato: 	text/html	
Fonte: 	Arquivo Brasileiro de Medicina Veterinária e Zootecnia  v.62 n.5 2010	
Fonte: 	info:eu-repo/semantics/openAccess