Data/hora: 06/06/2024 00:49:00

Provedor de dados: | 45
País: | Brazil
Título: | Effects of carprofen administered by different routes to control experimental uveitis in dogs
Autores: | Ribeiro,A.P.; Escobar,A.; Motheo,T.F.; Sakamoto,C.A.M.; Godoy,G.S.; Costa,M.A.N.; Laus,J.L.
Data: | 2010-04-01
Ano: | 2010
Palavras-chave: | Dog; Uveitis; Carprofen; Total protein; Prostaglandin E2.
Resumo: | Efficacy of carprofen, administered by different routes, was studied in experimental uveitis in dogs. Anterior chamber paracenteses was accomplished at two different moments (M0 and M1), with a five hour interval between them. At M0 and M1, 0.2mL of aqueous humor was collected and quantitation of total protein and prostaglandin E2 (PGE2) were determined. Four groups were formed (n=8), which received carprofen at the end of M0, by the following routes: subcutaneous (GIm), subconjunctival (GII), and topical (GIII). A fourth group that received no treatment was instituted (Control). Conjunctival histopathology of the GII animals was performed. In all groups, values of protein and PGE2 significantly enhanced at M1; however, they did not significantly change among groups at M1. Inflammatory exudate of acute character and mild hemorrhage were seen at histopathology after carprofen administration. Carprofen was unable to inhibit PGE2 synthesis and the protein influx to the anterior chamber by any of the tested routes. However, the reduction of 44% in protein levels (topical) suggests that the agent can be used by this route as an adjuvant to control uveitis in dogs.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000200010
Editor: | Universidade Federal de Minas Gerais, Escola de Veterinária
Relação: | 10.1590/S0102-09352010000200010
Formato: | text/html
Fonte: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia  v.62 n.2 2010
Fonte: | info:eu-repo/semantics/openAccess