Data/hora: 15/06/2024 14:28:40

Provedor de dados: | 45
País: | Brazil
Título: | Antiviral activity of bovine uterus and placenta induced by Newcastle disease virus
Autores: | Barreto Filho,J.B.; Marques Júnior,A.P.; Golgher,R.R.; Lopes,E.; Carvalho,P.H.A.; Rossi,R.O.D.S.
Data: | 2007-06-01
Ano: | 2007
Palavras-chave: | Cattle; Interferon; Placenta.
Resumo: | The antiviral activity profile of the uterus and fetal membranes from bovine placenta, induced by the Newcastle disease virus (NDV) throughout gestation, was investigated. Explants of the endometrium and caruncles were collected from the uterus, and amniochorion, allantochorion and cotyledons, from fetal placenta. Tissue cultures were induced with ~6.0 hemagglutinating units (HU) of NDV. Supernatants were concentrated 20 fold, filtered in 100kDa cut-off membranes and antiviral activity was titrated in MDBK x VSV system. Tissues of the uterus did not exhibit antiviral activity, while allantochorion and amniochorion produced antiviral factors throughout gestation. Antiviral factors were not related with IFN-alpha, gamma, tau or TNF-alpha. The antiviral activity pattern observed showed to be related with the development of fetal membranes and increased at the end of pregnancy. Such data suggest that IFN genes inducible by virus are present in fetal membranes of the cow placenta and their expression is dependent on the age of gestation.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352007000300006
Editor: | Universidade Federal de Minas Gerais, Escola de Veterinária
Relação: | 10.1590/S0102-09352007000300006
Formato: | text/html
Fonte: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia  v.59 n.3 2007
Fonte: | info:eu-repo/semantics/openAccess