Data/hora: 15/06/2024 23:54:14

Provedor de dados: 	45	
País: 	Brazil	
Título: 	Pharmacokinetics of sodium meclofenamate in pre-ruminant cattle	
Autores: 	Picco,E.J.; Diaz David,D.C.; Encinas,T.; Rubio,M.R.; Boggio,J.C.	
Data: 	2004-12-01	
Ano: 	2004	
Palavras-chave: 	Calf; Sodium meclofenamate; Pharmacokinetic; Pre-ruminant.	
Resumo: 	The pharmacokinetic profile of sodium meclofenamate, a non-steroidal antiinflammatory drug, was determined in six pre-ruminant calves after intravenous and intramuscular administration at a dose of 2.2mg/kg of body weight. Meclofenamate concentrations were measured using a high performance liquid chromatography assay. The pharmacokinetics of sodium meclofenamate after intravenous and intramuscular administration to calves were characterised by a rapid distribution phase (t½alpha ), 15.45± 4.85min and 23.14± 7.24min for the intravenous and intramuscular administration, respectively, followed by a longer elimination phase (t½beta ) after intramuscular treatment (17.55± 6.52h.). The apparent volume of distribution (Vd) of the drug after intravenous administration was moderate (0.72± 0.12l/kg), and high (3.51± 1.05l/kg) after intramuscular administration. This can be explained by the flip-flop effect or by enterohepatic shunting. The bioavailability achieved after intramuscular administration was 61%.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352004000600001	
Editor: 	Universidade Federal de Minas Gerais, Escola de Veterinária	
Relação: 	10.1590/S0102-09352004000600001	
Formato: 	text/html	
Fonte: 	Arquivo Brasileiro de Medicina Veterinária e Zootecnia  v.56 n.6 2004	
Fonte: 	info:eu-repo/semantics/openAccess