Data/hora: 09/06/2024 06:17:17

Provedor de dados: | 46
País: | Argentina
Título: | Mutation rate of 7 X-STRs of common use in population genetics
Autores: | Glesmann,Laura A.; Martina,Pablo F.; Vidal Rioja,Lidia; Catanesi,Cecilia I.
Data: | 2009-12-01
Ano: | 2009
Palavras-chave: | X chromosome; STR; Mutation rate; Population genetics.
Resumo: | Microsatellite loci analysis is a relevant tool in population genetic studies and also in paternity testing. In this field the X-chromosome STR loci are widely used for female offspring testing but their mutation rates are scarcely known. In this work we performed a mutation rate analysis of seven STR markers located in the X- chromosome specific region, in mother-son pairs and father-mother-daughter trios. Among 1015 allele transfers, we found only one change for a mother-daughter transmission in the DXS9898 locus, consisting of a loss of one single repeat. This finding allowed us to estimate a general mutation rate of &amp;#956;=9.85 x 10-4 (2.49 x 10-4 - 5.49 x 10-2) which can be applied to population studies. This value is consistent with other reports on autosomal STR loci, suggesting that similar molecular mechanisms are acting on X and autosomal repetitive markers.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1852-62332009000200002
Editor: | Sociedad Argentina de Genética
Formato: | text/html
Fonte: | BAG. Journal of basic and applied genetics  v.20 n.2 2009
Fonte: | info:eu-repo/semantics/openAccess