Data/hora: 11/06/2024 00:41:54

Provedor de dados: | 47
País: | Argentina
Título: | Interleukin-1&amp;#946; regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model
Autores: | Fontana,Vanina Andrea; Sanchez,Melisa; Cebral,Elisa; Calvo,Juan Carlos.
Data: | 2010-04-01
Ano: | 2010
Palavras-chave: | Cytokines; Embryo implantation; Placenta; Extracellular matrix.
Resumo: | Implantation is one of the most regulated processes in human reproduction, by endocrine and immunological systems. Cytokines are involved in embryo-maternal communication and an impaired balance could result in pregnancy loss. Here we investigated the effect of interleukin 1-&amp;#946; on the activity of two important metalloproteinases (MMP-2 and MMP-9) that are involved in extracellular matrix remodeling as well as the secretion of leptin, one of the reproductive hormones actively regulating their activity and secretion. We found that IL-1&amp;#946; activates matrix metalloproteinase activity as well as increases leptin secretion. We propose that this interleukin, through the regulation of leptin, in turn activates matrix metalloproteinases which results in an increased cytotrophoblast invasion.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452010000100005
Editor: | Sociedad Latinoamericana de Microscopía Electrónica.; Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina)
Formato: | text/html
Fonte: | Biocell  v.34 n.1 2010
Fonte: | info:eu-repo/semantics/openAccess