Data/hora: 05/06/2024 16:54:39

Provedor de dados: 	47	
País: 	Argentina	
Título: 	C2- and C4-position 17&amp;#946;-estradiol metabolites and their relation to breast cancer	
Autores: 	Joubert,Annie; Van Zyl,Hermia; Laurens,Johannes; Lottering,Mona-Liza.	
Data: 	2009-12-01	
Ano: 	2009	
Palavras-chave: 	Breast cancer; Estradiol metabolism; 2-methoxyestradiol.	
Resumo: 	C2- and C4-position 17&amp;#946;-estradiol metabolites play an important role in breast carcinogenesis. 2-Hydroxyestradiol and 4-hydroxyestradiol are implicated in tumorigenesis via two pathways. These pathways entail increased cell proliferation and the formation of reactive oxygen species that trigger an increase in the likelihood of deoxyribonucleic acid mutations. 2-Methoxyestradiol, a 17&amp;#946;-estradiol metabolite, however, causes induction of apoptosis in transformed and tumor cells; thus exhibiting an antiproliferative effect on tumor growth. The 4-hydroxyestradiol:2-methoxyestradiol and 2-hydroxyestradiol:2-methoxyestradiol ratios therefore ought to be taken into account as possible indicators of carcinogenesis.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452009000300001	
Editor: 	Sociedad Latinoamericana de Microscopía Electrónica.; Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina)	
Formato: 	text/html	
Fonte: 	Biocell  v.33 n.3 2009	
Fonte: 	info:eu-repo/semantics/openAccess