Data/hora: 10/06/2024 17:21:25

Provedor de dados: | 47
País: | Argentina
Título: | Agmatine inhibits hypoxia-induced TNF-alpha release from cultured retinal ganglion cells
Autores: | Hong,Samin; Park,Kyoungsoo; Kim,Chan Yun; Seong,Gong Je.
Data: | 2008-08-01
Ano: | 2008
Palavras-chave: | Retinal ganglion cell; Tumor necrosis factor-alpha; Hypoxia; Agmatine.
Resumo: | The effect of hypoxia on the release of tumor necrosis factor-alpha (TNF-alpha) in transformed rat retinal ganglion cells (RGCs) and the effect of agmatine on the hypoxia-induced production of TNF-alpha in RGCs were evaluated. RGCs were cultured under hypoxic conditions with 5% oxygen, with or without 100&amp;#956;M agmatine. The expression levels of TNF-alpha and its receptor-1 (TNF-R1) were investigated by Western blot analysis. After 6 hours of hypoxia, we noted an increase in TNF-alpha production in RGCs. Agmatine significantly reduced TNF-alpha level after 12 hours of hypoxic treatment. The expression of TNF-R1 was not affected by the hypoxia or agmatine treatment. Our results show that agmatine inhibits the TNF-alpha production of RGCs in hypoxic condition. These results demonstrate a possible neuroprotective mechanism for agmatine against hypoxic damage in RGCs.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452008000200006
Editor: | Sociedad Latinoamericana de Microscopía Electrónica.; Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina)
Formato: | text/html
Fonte: | Biocell  v.32 n.2 2008
Fonte: | info:eu-repo/semantics/openAccess