Data/hora: 11/06/2024 05:43:51

Provedor de dados: | 47
País: | Argentina
Título: | A likely role for a novel PH-domain containing protein, PEPP2, in connecting membrane and cytoskeleton
Autores: | Zou,Yi; Zhong,Wenping.
Data: | 2012-12-01
Ano: | 2012
Palavras-chave: | Microtubule; Membrane; Phosphoinositide; Microviscosity; Wortmannin.
Resumo: | PH domains (pleckstrin homology) are well known to bind membrane phosphoinositides with different specificities and direct PH domain-containing proteins to discrete subcellular apartments with assistances of alternative binding partners. PH domain-containing proteins are found to be involved in a wide range of cellular events, including signalling, cytoskeleton rearrangement and vesicular trafficking. Here we showed that a novel PH domain-containing protein, PEPP2, displayed moderate phosphoinositide binding specificity. Full length PEPP2 associated with both plasma membrane and microtubules. The membrane-associated PEPP2 nucleated at cell-cell contacts and the leading edge of migrating cells. Overexpression of PEPP2 increased membrane microviscosity, indicating a potential role of PEPP2 in regulating function of membrane and microtubules.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452012000300005
Editor: | Sociedad Latinoamericana de Microscopía Electrónica.; Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina)
Formato: | text/html
Fonte: | Biocell  v.36 n.3 2012
Fonte: | info:eu-repo/semantics/openAccess