Data/hora: 11/06/2024 07:12:48

Provedor de dados: 	47	
País: 	Argentina	
Título: 	A likely role for a novel PH-domain containing protein, PEPP2, in connecting membrane and cytoskeleton	
Autores: 	Zou,Yi; Zhong,Wenping.	
Data: 	2012-12-01	
Ano: 	2012	
Palavras-chave: 	Microtubule; Membrane; Phosphoinositide; Microviscosity; Wortmannin.	
Resumo: 	PH domains (pleckstrin homology) are well known to bind membrane phosphoinositides with different specificities and direct PH domain-containing proteins to discrete subcellular apartments with assistances of alternative binding partners. PH domain-containing proteins are found to be involved in a wide range of cellular events, including signalling, cytoskeleton rearrangement and vesicular trafficking. Here we showed that a novel PH domain-containing protein, PEPP2, displayed moderate phosphoinositide binding specificity. Full length PEPP2 associated with both plasma membrane and microtubules. The membrane-associated PEPP2 nucleated at cell-cell contacts and the leading edge of migrating cells. Overexpression of PEPP2 increased membrane microviscosity, indicating a potential role of PEPP2 in regulating function of membrane and microtubules.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452012000300005	
Editor: 	Sociedad Latinoamericana de Microscopía Electrónica.; Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina)	
Formato: 	text/html	
Fonte: 	Biocell  v.36 n.3 2012	
Fonte: 	info:eu-repo/semantics/openAccess