Data/hora: 16/06/2024 00:50:57

Provedor de dados: 	48	
País: 	Chile	
Título: 	Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population	
Autores: 	BORASKA,VESNA; ŠKRABI,VESELIN; IKEŠ ULI,VEDRANA; BEI,KRISTIJAN; KAPITANOVI,SANJA; ZEMUNIK,TATIJANA.	
Data: 	2008-01-01	
Ano: 	2008	
Palavras-chave: 	Type 1 diabetes; Tumor necrosis factor gene (TNF); Polymorphism; Genetic epidemiology; Croatia.	
Resumo: 	Type 1 diabetes mellitus (TIDM) is an autoimmune disease characterized by the destruction of pancreatic p cells. Tumor necrosis factor (TNF) is a pleotropic cytokine with potent immunomodulatory and inflammatory activity. Association studies of TNF polymorphisms and type 1 diabetes (TIDM) frequently demonstrated TNF involvement with TIDM. Although TNF may play an important role in the pathogenesis of TIDM, the genetic association of TNF región with the disease has not been conclusive because of the strong linkage disequilibrium with HLA genes. In this study, we examined two TNF promoter variants (rs 1800629 at position -308, and rs361525 at position -238) for TIDM association in 233 patients and 144 controls from the population of South Croatia. A higher frequency of TNF -308 A alíele and also, a more frequent specific -308A -238G haplotype in TIDM patients were observed with a limited significance. However, we did not find strong evidence of association of TNF promoter polymorphisms with TIDM. In order to elucidate the trae contribution of TNF to TIDM susceptibility in our population, more comprehensive studies with HLA adjustment in a larger sample are required.	
Tipo: 	Journal article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000200005	
Editor: 	Sociedad de Biología de Chile	
Formato: 	text/html	
Fonte: 	Biological Research  v.41 n.2 2008