Data/hora: 07/06/2024 09:20:28

Provedor de dados: | 48
País: | Chile
Título: | Cytoprotective and suicidal signaling in oxidative stress
Autores: | Videla,Luis A.
Data: | 2010-01-01
Ano: | 2010
Palavras-chave: | Oxidative stress; Thyroid hormone; Liver preconditioning; Obesity; Insulin resistance; Non-alcoholic fatty liver disease.
Resumo: | Oxidative stress is an imbalance between pro-oxidants and antioxidants in favor of the pro-oxidants, leading to different responses depending on the level of pro-oxidants achieved and the duration of exposure. In this article, we discuss the cytoprotective or suicidal signaling mechanisms associated with oxidative stress by addressing: (i) the development of an acute and mild pro-oxidant state by thyroid hormone administration eliciting the redox upregulation of the expression of proteins affording cell protection as a preconditioning strategy against ischemia-reperfusion liver injury; and (ii) the role of prolonged and severe oxidative stress and insulin resistance as determinant factors in the pathogenesis of non-alcoholic fatty liver disease associated with obesity.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300014
Editor: | Sociedad de Biología de Chile
Formato: | text/html
Fonte: | Biological Research  v.43 n.3 2010