Data/hora: 01/06/2024 01:33:11

Provedor de dados: 	48	
País: 	Chile	
Título: 	Nitric Oxide: Oxygen Radical Interactions in Atherosclerosis	
Autores: 	RUBBO,HOMERO; BATTHYANY,CARLOS; RADI,RAFAEL.	
Data: 	2000-01-01	
Ano: 	2000	
Palavras-chave: 	Antioxidants; Free radicals; Lipid oxidation; Low density lipoprotein oxidation; Nitric oxide; Peroxynitrite.	
Resumo: 	Atherosclerosis is one of the most common diseases and the principal cause of death in western civilization. The pathogenesis of this disease can be explained on the basis of the ‘oxidative-modification hypothesis,’ which proposes that low-density lipoprotein (LDL) oxidation represents a key early event. Nitric oxide (.NO) regulates critical lipid membrane and lipoprotein oxidation events by a) contributing to the formation of more potent secondary oxidants from superoxide (i.e.: peroxynitrite), and b) its antioxidant properties through termination reactions with lipid radicals to possibly less reactive secondary nitrogen-containing products (LONO, LOONO). Relative rates of production and steady state concentrations of superoxide and .NO and cellular sites of production will profoundly influence the expression of differential oxidant injury-enhancing and protective effects of .NO. Full understanding of the physiological roles of .NO, coupled with detailed insight into .NO regulation of oxygen radical-dependent reactions, will yield a more rational basis for intervention strategies directed toward oxidant-dependent atherogenic processes	
Tipo: 	Journal article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200017	
Editor: 	Sociedad de Biología de Chile	
Formato: 	text/html	
Fonte: 	Biological Research  v.33 n.2 2000