Data/hora: 06/06/2024 01:12:47

Provedor de dados: 	48	
País: 	Chile	
Título: 	Characterization of mitochondrial iron uptake in HepG2 cells	
Autores: 	MAZARIEGOS,DORA INÉS; CABANTCHIK,Z. IOAV; CASSELS,BRUCE K; NÚÑEZ,MARCO TULIO.	
Data: 	2006-01-01	
Ano: 	2006	
Palavras-chave: 	Mitochondria; Iron homeostasis; RPA; HepG2 cells.	
Resumo: 	There is increasing evidence that accumulation of redox-active iron in mitochondria leads to oxidative damage and contributes to various neurodegenerative diseases, such as Friedreich's ataxia and Parkinson's disease. In this work, we examined the existence of regulatory mechanisms for mitochondrial iron uptake and storage. To that end, we used rhodamine B- [(1,10-phenanthrolin-5-yl)amino carbonyl ] benzyl ester, a new fluorescent iron-sensitive probe that is targeted specifically to the mitochondrion. We found that extracellular iron was incorporated readily into mitochondria in an apparently saturable process. Moreover, the rate of iron incorporation responded to the Fe status of the cell, an indication that the mitochondrion actively regulates its iron content.	
Tipo: 	Journal article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100024	
Editor: 	Sociedad de Biología de Chile	
Formato: 	text/html	
Fonte: 	Biological Research  v.39 n.1 2006