Data/hora: 06/06/2024 04:22:28

Provedor de dados: | 48
País: | Chile
Título: | Compensatory responses induced by oxidative stress in Alzheimer disease
Autores: | MOREIRA,PAULA I; ZHU,XIONGWEI; LIU,QUAN; HONDA,KAZUHIRO; SIEDLAK,SANDRA L; HARRIS,PEGGY L; SMITH,MARK A.; PERRY,GEORGE.
Data: | 2006-01-01
Ano: | 2006
Palavras-chave: | Alzheimer disease; Antioxidant therapy; Mitochondria; Oxidative stress; Redox metals.
Resumo: | Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. In the first stage of development of the disease, amyloid-&amp;#946; deposition and hyperphosphorylated tau function as compensatory responses and downstream adaptations to ensure that neuronal cells do not succumb to oxidative damage. These findings suggest that Alzheimer disease is associated with a novel balance in oxidant homeostasis.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100002
Editor: | Sociedad de Biología de Chile
Formato: | text/html
Fonte: | Biological Research  v.39 n.1 2006