Data/hora: 02/06/2024 12:48:34

Provedor de dados: | 48
País: | Chile
Título: | Integrated analyses of copy number variations and gene differential expression in lung squamous-cell carcinoma
Autores: | Yang,Zhao; Zhuan,Bing; Yan,Ying; Jiang,Simin; Wang,Tao.
Data: | 2015-01-01
Ano: | 2015
Palavras-chave: | Lung squamous-cell carcinoma; Differentially expressed genes; Copy number variation; Copy number variation-driven genes.
Resumo: | BACKGROUND: Although numerous efforts have been made, the pathogenesis underlying lung squamous-cell carcinoma (SCC) remains unclear. This study aimed to identify the CNV-driven genes by an integrated analysis of both the gene differential expression and copy number variation (CNV). RESULTS: A higher burden of the CNVs was found in 10-50 kb length. The 16 CNV-driven genes mainly located in chr 1 and chr 3 were enriched in immune response &amp;#91;e.g. complement factor H (CFH) and Fc fragment of IgG, low affinity Ilia, receptor (FCGR3A)&amp;#93;, starch and sucrose metabolism &amp;#91;e.g. amylase alpha 2A (AMY2A)&amp;#93;. Furthermore, 38 TFs were screened for the 9 CNV-driven genes and then the regulatory network was constructed, in which the GATA-binding factor 1, 2, and 3 (GATA 1, GATA2, GATA3) jointly regulated the expression of TP63. CONCLUSIONS: The above CNV-driven genes might be potential contributors to the development of lung SCC.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100047
Editor: | Sociedad de Biología de Chile
Formato: | text/html
Fonte: | Biological Research  v.48 2015