Data/hora: 07/06/2024 01:51:25

Provedor de dados: | 48
País: | Chile
Título: | Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation
Autores: | LÓPEZ-ALARCÓN,CAMILO; SPEISKY,HERNÁN; LISSI,EDUARDO.
Data: | 2007-01-01
Ano: | 2007
Palavras-chave: | 5-Aminosalicylic acid; Antioxidant; LDL oxidation.
Resumo: | The antioxidant effect of 5-Aminosalicylic acid (5-ASA) on copper-mediated LDL oxidation was followed either by the emitted chemiluminiscence (CL) or by UV-vis spectroscopy. 5-ASA addition extends the lag phase in a concentration-dependent manner without changes in the rate of the process in the autoaccelerated phase. The antioxidant behavior of 5-ASA was very similar to that of Trolox, a very efficient water soluble antioxidant. The copper-binding capacity of 5-ASA was evaluated by UV-visible spectroscopy. The addition of copper to a 5-ASA solution increases the absorbance at 332 nm and generates a new band at 298 nm. These changes in the UV-vis spectra indicate formation of a complex between 5-ASA and copper. However, LDL protection by 5-ASA is unrelated to its copper chelating capacity
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200006
Editor: | Sociedad de Biología de Chile
Formato: | text/html
Fonte: | Biological Research  v.40 n.2 2007