Data/hora: 14/06/2024 17:22:45

Provedor de dados: | 48
País: | Chile
Título: | Relaxant effects of a hydroalcoholic extract of Ruta graveolens on isolated rat tracheal rings
Autores: | Águila,Luis; Ruedlinger,Jenny; Mansilla,Karina; Ordenes,José; Salvatici,Raúl; Campos,Rui Ribeiro de; Romero,Fernando.
Data: | 2015-01-01
Ano: | 2015
Palavras-chave: | Ruta graveolens; Trachea-relaxant; Plant extract.
Resumo: | BACKGROUND: Ruta graveolens L. (R. graveolens) is a medicinal plant employed in non-traditional medicines that has various therapeutic properties, including anthelmintic, and vasodilatory actions, among others. We evaluated the trachea-relaxant effects of hydroalcoholic extract of R. graveolens against potassium chloride (KCl)- and carbachol-induced contraction of rat tracheal rings in an isolated organ bath. RESULTS: The results showed that the airway smooth muscle contraction induced by the depolarizing agent (KCl) and cholinergic agonist (carbachol) was markedly reduced by R. graveolens in a concentration-dependent manner, with maximum values of 109 ± 7.9 % and 118 ± 2.6 %, respectively (changes in tension expressed as positive percentages of change in proportion to maximum contraction), at the concentration of 45 &amp;#956;g/mL (half-maximal inhibitory concentration IC50: 35.5 &amp;#956;g/mL and 27.8 &amp;#956;g/mL for KCl- and carbachol-induced contraction, respectively). Additionally, the presence of R. graveolens produced rightward parallel displacement of carbachol dose-response curves and reduced over 35 % of the maximum smooth muscle contraction. CONCLUSIONS: The hydroalcoholic extract of R. graveolens exhibited relaxant activity on rat tracheal rings. The results suggest that the trachea-relaxant effect is mediated by a non-competitive antagonistic mechanism. More detailed studies are needed to identify the target of the inhibition, and to determine more precisely the pharmacological mechanisms involved in the observed biological effects.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100028
Editor: | Sociedad de Biología de Chile
Formato: | text/html
Fonte: | Biological Research  v.48 2015