Data/hora: 06/06/2024 09:20:33

Provedor de dados: 	5	
País: 	France	
Título: 	Expression, tissue localization and synergy of antimicrobial peptides and proteins in the immune response of the oyster Crassostrea gigas	
Autores: 	Schmitt, Paulina; De Lorgeril, Julien; Gueguen, Yannick; Destoumieux-garzon, Delphine; Bachere, Evelyne.	
Data: 	2012-07	
Ano: 	2012	
Palavras-chave: 	Pacific oyster; Bivalve mollusk; Innate immunity; Bactericidal/permeability-increasing protein; Proline-rich peptide; Defensin; Vibrio.	
Resumo: 	Diverse families of antimicrobial peptides and proteins have been described in oysters. We investigated here how antimicrobials are involved in the immune response against a pathogenic strain of Vibrio splendidus. Oyster antimicrobials were shown to display a wide variety of expression profiles in hemocyte populations and tissues. Oyster defensins are constitutively expressed in specific tissues such as mantle (Cg-Defm) or hemocytes (Cg-Defhs), while Cg-BPI is inducible and Cg-Prp appears down-regulated in hemocytes upon infection. The migratory behavior of hemocytes that express the different antimicrobials was found to be involved in the oyster response to a pathogenic Vibrio infection. Indeed, it contributes to colocalize several antimicrobials that were shown here to have synergistic activities. We propose that such a synergy, which was evidenced both within and between families of antimicrobials, might compensate for the low concentration of antimicrobials in oyster tissues. (c) 2012 Elsevier Ltd. All rights reserved.	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	http://archimer.ifremer.fr/doc/00093/20382/18267.pdf

DOI:10.1016/j.dci.2012.01.004	
Editor: 	Elsevier Sci Ltd	
Relação: 	http://archimer.ifremer.fr/doc/00093/20382/	
Formato: 	application/pdf	
Fonte: 	Developmental And Comparative Immunology (0145-305X) (Elsevier Sci Ltd), 2012-07 , Vol. 37 , N. 3-4 , P. 363-370	
Fonte: 	2012 Elsevier Ltd. All rights reserved.