Data/hora: 16/06/2024 00:31:40

Provedor de dados: 	5	
País: 	France	
Título: 	Écophysiologie des dinoflagellés du genre Azadinium, production toxinique et transfert trophique vers les mollusques bivalves	
Autores: 	Jauffrais, Thierry.	
Data: 	2012-10	
Ano: 	2012	
Palavras-chave: 	Azadinium spinosum; Mytilus edulis; Azaspiracides; Phycotoxines; Dinoflagellés; Écophysiologie; CL-SM/SM; Azadinium spinosum; Mytilus edulis; Azaspiracids; Phycotoxins; Dinoflagellate; Ecophysiology; LC-MS/MS.	
Resumo: 	This study has been conducted in order to develop the analysis of AZAs and to produce AZAs from A. spinosum culture. It also aimed at studying the effect of environmental and nutritional factors on growth and toxin production. The study also demonstrated a link between A. spinosum and the accumulation of AZAs in shellfish, followed by the clarification of the processes of accumulation, detoxification and biotransformation of AZAs into mussels. A quantitative analysis of AZAs in A. spinosum cultures was developed, and the formation and structure of the AZA methylated analogues was explained and minimised. This work also demonstrated the feasibility of a sustainable production of AZAs from A. spinosum culture and highlighted the main factors influencing growth and toxin production of A. spinosum. Using these results, mussel contaminations were performed and demonstrated for the first time the direct link between A. spinosum and AZA accumulation into mussels. Furthermore, a rapid AZA accumulation above the regulatory limit was observed within 6 h of exposure. These experiments also highlighted the rapid biotransformation of AZA into analogues in shellfish and clarified their kinetics of appearance. Consequently, AZA biotransformation pathways were proposed for different AZA analogues. AZA detoxification was also studied and showed a detoxification with two compartments. Finally, two recent studies demonstrated the negative effect of A. spinosum on the feeding activity of mussels as well as the ability of mussels to accumulate AZA from dissolved or particulate forms.	
Tipo: 	Text	
Idioma: 	Francês	
Identificador: 	http://archimer.ifremer.fr/doc/00111/22217/19891.pdf	
Editor: 	Université de Nantes	
Relação: 	http://archimer.ifremer.fr/doc/00111/22217/	
Formato: 	application/pdf	
Fonte: 	2012 Université de Nantes