Data/hora: 10/06/2024 17:58:22

Provedor de dados: | 5
País: | France
Título: | Optimal proteome allocation and the temperature dependence of microbial growth laws
Autores: | Mairet, Francis; Gouzé, Jean-luc; De Jong, Hidde.
Data: | 2021-03
Ano: | 2021
Resumo: | Although the effect of temperature on microbial growth has been widely studied, the role of proteome allocation in bringing about temperature-induced changes remains elusive. To tackle this problem, we propose a coarse-grained model of microbial growth, including the processes of temperature-sensitive protein unfolding and chaperone-assisted (re)folding. We determine the proteome sector allocation that maximizes balanced growth rate as a function of nutrient limitation and temperature. Calibrated with quantitative proteomic data for Escherichia coli, the model allows us to clarify general principles of temperature-dependent proteome allocation and formulate generalized growth laws. The same activation energy for metabolic enzymes and ribosomes leads to an Arrhenius increase in growth rate at constant proteome composition over a large range of temperatures, whereas at extreme temperatures resources are diverted away from growth to chaperone-mediated stress responses. Our approach points at risks and possible remedies for the use of ribosome content to characterize complex ecosystems with temperature variation.
Tipo: | Text
Idioma: | Inglês

Identificador:

https://archimer.ifremer.fr/doc/00686/79829/82633.pdf

https://archimer.ifremer.fr/doc/00686/79829/82634.pdf

https://archimer.ifremer.fr/doc/00686/79829/82635.pdf

DOI:10.1038/s41540-021-00172-y

https://archimer.ifremer.fr/doc/00686/79829/

Editor: | Springer Science and Business Media LLC
Formato: | application/pdf
Fonte: | Npj Systems Biology And Applications (2056-7189) (Springer Science and Business Media LLC), 2021-03 , Vol. 7 , N. 1 , P. 14 (11p.)

Fonte:

info:eu-repo/semantics/openAccess

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