Data/hora: 06/06/2024 18:06:40

Provedor de dados: | 5
País: | France
Título: | SAR of Sponge-Inspired Hemibastadin Congeners Inhibiting Blue Mussel PhenolOxidase
Autores: | Niemann, Hendrik; Hagenow, Jens; Chung, Mi-young; Hellio, Claire; Weber, Horst; Proksch, Peter.
Data: | 2015-05
Ano: | 2015
Palavras-chave: | Antifouling; Hemibastadin; Phenoloxidase; Sponges; Copper; Mytilus edulis.
Resumo: | Hemibastadin derivatives, including the synthetically-derived 5,5-dibromohemibastadin-1 (DBHB), are potent inhibitors of blue mussel phenoloxidase (PO), which is a key enzyme involved in the firm attachment of this invertebrate to substrates and, thus, a promising molecular target for anti-fouling research. For a systematic investigation of the enzyme inhibitory activity of hemibastadin derivatives, we have synthesized nine new congeners, which feature structural variations of the DBHB core structure. These structural modifications include, e.g., different halogen substituents present at the aromatic rings, different amine moieties linked to the (E)-2-(hydroxyimino)-3-(4-hydroxyphenyl)propionic acid, the presence of free vs. substituted aromatic hydroxyl groups and a free vs. methylated oxime group. All compounds were tested for their inhibitory activity towards the target enzyme in vitro, and IC50 values were calculated. Derivatives, which structurally closely resemble sponge-derived hemibastadins, revealed superior enzyme inhibitory properties vs. congeners featuring structural moieties that are absent in the respective natural products. This study suggests that natural selection has yielded structurally-optimized antifouling compounds.
Tipo: | Text
Idioma: | Inglês

Identificador:

https://archimer.ifremer.fr/doc/00273/38432/73167.pdf

https://archimer.ifremer.fr/doc/00273/38432/73168.pdf

DOI:10.3390/md13053061

https://archimer.ifremer.fr/doc/00273/38432/

Editor: | Mdpi Ag
Formato: | application/pdf
Fonte: | Marine Drugs (1660-3397) (Mdpi Ag), 2015-05 , Vol. 13 , N. 5 , P. 3061-3071

Fonte:

info:eu-repo/semantics/openAccess

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