Data/hora: 02/06/2024 14:44:49

Provedor de dados: 	5	
País: 	France	
Título: 	Multi- and transgenerational effects following early-life exposure of zebrafish to permethrin and coumarin 47: Impact on growth, fertility, behavior and lipid metabolism	
Autores: 	Blanc, Mélanie; Cormier, Bettie; Hyötyläinen, Tuulia; Krauss, Martin; Scherbak, Nikolai; Cousin, Xavier; Keiter, Steffen H.	
Data: 	2020-12	
Ano: 	2020	
Palavras-chave: 	Pyrethroid; Endocrine disrupter; Epigenetic; Transgenerational; Neurotoxic.	
Resumo: 	Transgenerational effects induced by environmental stressors are a threat to ecosystems and human health. However, there is still limited observation and understanding of the potential of chemicals to influence life outcomes over several generations. In the present study, we investigated the effects of two environmental contaminants, coumarin 47 and permethrin, on exposed zebrafish (F0) and their progeny (F1–F3). Coumarin 47 is commonly found in personal care products and dyes, whereas permethrin is used as a domestic and agricultural pyrethroid insecticide/insect repellent. Zebrafish (F0) were exposed during early development until 28 days post-fertilization and their progeny (F1–F3) were bred unexposed. On one hand, the effects induced by coumarin 47 suggest no multigenerational toxicity. On the other hand, we found that behavior of zebrafish larvae was significantly affected by exposure to permethrin in F1 to F3 generations with some differences depending on the concentration. This suggests persistent alteration of the neural or neuromuscular function. In addition, lipidomic analyses showed that permethrin treatment was partially correlated with lysophosphatidylcholine levels in zebrafish, an important lipid for neurodevelopment. Overall, these results stress out one of the most widely used pyrethroids can trigger long-term, multi- and possibly transgenerational changes in the nervous system of zebrafish. These neurobehavioral changes echo the effects observed under direct exposure to high concentrations of permethrin and therefore call for more research on mechanisms underlying effect inheritance.	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	https://archimer.ifremer.fr/doc/00652/76393/77411.pdf

https://archimer.ifremer.fr/doc/00652/76393/77412.docx

https://archimer.ifremer.fr/doc/00652/76393/77413.xlsx

DOI:10.1016/j.ecoenv.2020.111348

https://archimer.ifremer.fr/doc/00652/76393/	
Editor: 	Elsevier BV	
Formato: 	application/pdf	
Fonte: 	Ecotoxicology And Environmental Safety (0147-6513) (Elsevier BV), 2020-12 , Vol. 205 , P. 111348 (8p.)	
Fonte: 	info:eu-repo/semantics/openAccess

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