Data/hora: 06/06/2024 07:47:16

Provedor de dados: | 5
País: | France
Título: | Natural resistance to Fasciola hepatica (Trematoda) in Pseudosuccinea columella snails: A review from literature and insights from comparative “omic” analyses
Autores: | Alba, Annia; Tetreau, Guillaume; Chaparro, Cristian; Sánchez, Jorge; Vázquez, Antonio A.; Gourbal, Benjamin.
Data: | 2019-12
Ano: | 2019
Palavras-chave: | Transcriptome; Albumen gland; Allocation of resources; Response to stress; Immune defense; Cost of resistance.
Resumo: | The snail Pseudosuccinea columella is one of the main vectors of the medically-important trematode Fasciola hepatica. In Cuba, the existence of natural P. columella populations that are either susceptible or resistant to F. hepatica infection offers a unique snail-parasite for study of parasite-host compatibility and immune function in gastropods. Here, we review all previous literature on this system and present new “omic” data that provide a molecular baseline of both P. columella phenotypes from naïve snails. Comparison of whole snail transcriptomes (RNAseq) and the proteomes of the albumen gland (2D-electrophoresis, MS) revealed that resistant and susceptible strains differed mainly in an enrichment of particular biological processes/functions and a greater abundance of proteins/transcripts associated with immune defense/stress response in resistant snails. These results indicate a differential allocation of molecular resources to self-maintenance and survival in resistant P. columella that may cause enhanced responsiveness to stressors (i.e. F. hepatica infection or tolerance to variations in environmental pH/total water hardness), possibly as trade-off against reproduction and the ecological cost of resistance previously suggested in resistant populations of P. columella.
Tipo: | Text
Idioma: | Inglês

Identificador:

https://archimer.ifremer.fr/doc/00509/62039/66180.pdf

DOI:10.1016/j.dci.2019.103463

https://archimer.ifremer.fr/doc/00509/62039/

Editor: | Elsevier BV
Formato: | application/pdf
Fonte: | Developmental And Comparative Immunology (0145-305X) (Elsevier BV), 2019-12 , Vol. 101 , P. 103463 (14p.)

Fonte:

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