Data/hora: 14/06/2024 00:07:26

Provedor de dados: | 5
País: | France
Título: | Differential distribution and defence involvement of antimicrobial peptides in mussel
Autores: | Mitta, Guillaume; Vandenbulcke, Franck; Noel, Thierry; Romestand, Bernard; Beauvillain, Jean Claude; Salzet, Michel; Roch, Philippe.
Data: | 2000-08
Ano: | 2000
Palavras-chave: | Innate immunity; Hemocyte; Mussel; Myticin; Mytilin; Defensin; Antimicrobial.
Resumo: | In previous papers, we characterised 3 types of 4-kDa, cysteine-rich, cationic antimicrobial peptides: MGDs (for Mytilus galloprovincialis defensins), mytilins and myticins, which are abundant in the mussel hemocytes. In the present work, me revealed a differential distribution of the cells expressing the different genes. In addition, using confocal and electron microscopy, we confirmed that defensins and mytilins were partially located in different sub-types of circulating hemocytes although the peptides can be located in the same cell, and even in the same granule. We also demonstrated that mytilins exert their microbicidal effect within the cells through the process of phagosome-mytilin granule fusion leading to the co-location of ingested bacteria and mytilins.
Tipo: | Text
Idioma: | Inglês
Identificador: | http://archimer.ifremer.fr/doc/2000/publication-413.pdf
Editor: | Company of Biologists
Relação: | http://archimer.ifremer.fr/doc/00000/413/
Formato: | application/pdf
Fonte: | Journal of Cell Science (0021-9533) (Company of Biologists), 2000-08 , Vol. 113 , N. 15 , P. 2759-2769
Fonte: | The Company of Biologists Limited 2000