Data/hora: 11/06/2024 08:21:10

Provedor de dados: 	5	
País: 	France	
Título: 	Fish Reproduction Is Disrupted upon Lifelong Exposure to Environmental PAHs Fractions Revealing Different Modes of Action	
Autores: 	Vignet, Caroline; Larcher, Thibaut; Davail, Blandine; Joassard, Lucette; Le Menach, Karyn; Guionnet, Tiphaine; Lyphout, Laura; Ledevin, Mireille; Goubeau, Manon; Budzinski, Helene; Begout, Marie-laure; Cousin, Xavier.	
Data: 	2016-12	
Ano: 	2016	
Palavras-chave: 	Polycyclic aromatic hydrocarbons; Zebrafish; Spawning success; Fertilization; Gonad differentiation; Molecular mechanisms.	
Resumo: 	Polycyclic aromatic hydrocarbons (PAHs) constitute a large family of organic pollutants emitted in the environment as complex mixtures, the compositions of which depend on origin. Among a wide range of physiological defects, PAHs are suspected to be involved in disruption of reproduction. In an aquatic environment, the trophic route is an important source of chronic exposure to PAHs. Here, we performed trophic exposure of zebrafish to three fractions of different origin, one pyrolytic and two petrogenic. Produced diets contained PAHs at environmental concentrations. Reproductive traits were analyzed at individual, tissue and molecular levels. Reproductive success and cumulative eggs number were disrupted after exposure to all three fractions, albeit to various extents depending on the fraction and concentrations. Histological analyses revealed ovary maturation defects after exposure to all three fractions as well as degeneration after exposure to a pyrolytic fraction. In testis, hypoplasia was observed after exposure to petrogenic fractions. Genes expression analysis in gonads has allowed us to establish common pathways such as endocrine disruption or differentiation/maturation defects. Taken altogether, these results indicate that PAHs can indeed disrupt fish reproduction and that different fractions trigger different pathways resulting in different effects.	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	https://archimer.ifremer.fr/doc/00355/46641/46465.pdf

https://archimer.ifremer.fr/doc/00355/46641/46466.pdf

DOI:10.3390/toxics4040026

https://archimer.ifremer.fr/doc/00355/46641/	
Editor: 	Mdpi Ag	
Formato: 	application/pdf	
Fonte: 	Toxics (2305-6304) (Mdpi Ag), 2016-12 , Vol. 4 , N. 4 , P. 26 (1-18)	
Fonte: 	2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

info:eu-repo/semantics/openAccess

restricted use