Data/hora: 03/06/2024 06:08:02

Provedor de dados: 	5	
País: 	France	
Título: 	Infectivity of GI and GII noroviruses established from oyster related outbreaks	
Autores: 	Thebault, Anne; Teunis, Peter F. M.; Le Pendu, Jacques; Le Guyader, Soizick; Denis, Jean-baptiste.	
Data: 	2013-06	
Ano: 	2013	
Palavras-chave: 	Norovirus; Shellfish; Bayesian analysis; Dose-response relationship; Fucosyltransferases.	
Resumo: 	Noroviruses (NoVs) are the major cause of acute epidemic gastroenteritis in industrialized countries. Outbreak strains are predominantly genogroup II (GII) NoV, but genogroup I (GI) strains are regularly found in oyster related outbreaks. The prototype Norwalk virus (GI), has been shown to have high infectivity in a human challenge study. Whether other NoVs are equally infectious via natural exposure remains to be established. Human susceptibility to NoV is partly determined by the secretor status (Se+/-). Data from five published oyster related outbreaks were analyzed in a Bayesian framework. Infectivity estimates where high and consistent with NV(GI) infectivity, for both GII and GI strains. The median and CI95 probability of infection and illness, in Se+ subjects, associated with exposure to a mean of one single NoV genome copy were around 0.29[0.015-0.61] for GI and 0.4[0.04-0.61] for GII, and for illness 0.13[0.007-0.39] for GI and 0.18[0.017-0.42] for GII. Se-subjects were strongly protected against infection. The high infectivity estimates for Norwalk virus GI and GII, makes NoVs critical target for food safety regulations.	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	http://archimer.ifremer.fr/doc/00148/25927/24030.pdf

DOI:10.1016/j.epidem.2012.12.004	
Editor: 	Elsevier Science Bv	
Relação: 	http://archimer.ifremer.fr/doc/00148/25927/	
Formato: 	application/pdf	
Fonte: 	Epidemics (1755-4365) (Elsevier Science Bv), 2013-06 , Vol. 5 , N. 2 , P. 98-110	
Fonte: 	2013 Elsevier B.V. All rights reserved.