Data/hora: 06/06/2024 08:44:15

Provedor de dados: | 5
País: | France
Título: | Advances in gastropod immunity from the study of the interaction between the snail Biomphalaria glabrata and its parasites: A review of research progress over the last decade
Autores: | Coustau, C.; Gourbal, B.; Duval, D.; Yoshino, T. P.; Adema, C. M.; Mitta, Guillaume.
Data: | 2015-09
Ano: | 2015
Palavras-chave: | Biomphalaria glabrata; Schistosoma mansoni; Echinostoma caproni; Immunity; Compatibility.
Resumo: | This review summarizes the research progress made over the past decade in the field of gastropod immunity resulting from investigations of the interaction between the snail Biomphalaria glabrata and its trematode parasites. A combination of integrated approaches, including cellular, genetic and comparative molecular and proteomic approaches have revealed novel molecular components involved in mediating Biomphalaria immune responses that provide insights into the nature of host-parasite compatibility and the mechanisms involved in parasite recognition and killing. The current overview emphasizes that the interaction between B. glabrata and its trematode parasites involves a complex molecular crosstalk between numerous antigens, immune receptors, effectors and anti-effector systems that are highly diverse structurally and extremely variable in expression between and within host and parasite populations. Ultimately, integration of these molecular signals will determine the outcome of a specific interaction between a B. glabrata individual and its interacting trematodes. Understanding these complex molecular interactions and identifying key factors that may be targeted to impairment of schistosome development in the snail host is crucial to generating new alternative schistosomiasis control strategies.
Tipo: | Text
Idioma: | Inglês

Identificador:

https://archimer.ifremer.fr/doc/00276/38718/38622.pdf

DOI:10.1016/j.fsi.2015.01.036

https://archimer.ifremer.fr/doc/00276/38718/

Editor: | Academic Press Ltd- Elsevier Science Ltd
Formato: | application/pdf
Fonte: | Fish &amp; Shellfish Immunology (1050-4648) (Academic Press Ltd- Elsevier Science Ltd), 2015-09 , Vol. 46 , N. 1 , P. 5-16

Fonte:

2015 Elsevier Ltd. All rights reserved

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