Data/hora: 06/06/2024 15:31:54

Provedor de dados: 	5	
País: 	France	
Título: 	(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach	
Autores: 	Cosseau, Celine; Wolkenhauer, Olaf; Padalino, Gilda; Geyer, Kathrin K.; Hoffmann, Karl F.; Grunau, Christoph.	
Data: 	2017-04	
Ano: 	2017	
Resumo: 	The GxE concept, in which genotype x environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by 'inheritance system'. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	https://archimer.ifremer.fr/doc/00385/49607/71826.pdf

https://archimer.ifremer.fr/doc/00385/49607/71827.pdf

DOI:10.1016/j.pt.2016.12.002

https://archimer.ifremer.fr/doc/00385/49607/	
Editor: 	Elsevier Sci Ltd	
Formato: 	application/pdf	
Fonte: 	Trends In Parasitology (1471-4922) (Elsevier Sci Ltd), 2017-04 , Vol. 33 , N. 4 , P. 285-294	
Fonte: 	info:eu-repo/semantics/openAccess

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