Data/hora: 01/06/2024 18:21:43

Provedor de dados: 	5	
País: 	France	
Título: 	Dietary exposure of juvenile common sole (Solea solea L.) to polybrominated diphenyl ethers (PBDEs): Part 2. Formation, bioaccumulation and elimination of hydroxylated metabolites	
Autores: 	Munschy, Catherine; Moisan, Karine; Tixier, Celine; Pacepavicius, G.; Alaee, M.	
Data: 	2010-12	
Ano: 	2010	
Palavras-chave: 	Marine flatfish; PBDEs; Bioaccumulation; Biotransformation; Hydroxylated metabolites.	
Resumo: 	The uptake, elimination and transformation of six PBDE congeners (BDE-28, -47, -99, -100, -153, -209) were studied in juvenile common sole (Solea solea L) exposed to spiked contaminated food over a three-month period, and then depurated over a five-month period. Methoxylated (MeO-) and hydroxylated (OH-) PBDEs were determined in fish plasma exposed to PBDEs and compared to those obtained in control fish. While all MeO- and some OH- congeners identified in fish plasma were found to originate from non-metabolic sources, several OH- congeners, i.e., OH-tetraBDEs and OH-pentaBDEs, were found to originate from fish metabolism. Among these, 4 '-OH-BDE-49 was identified as a BDE-47 metabolite. Congener 4 '-OH-BDE-101, identified here for the first time, may be the result of BDE-99 metabolic transformation. Our results unequivocally showed that PBDEs are metabolised in juvenile sole via the formation of OH- metabolites. However, this was not a major biotransformation route compared to biotransformation through debromination. (C) 2010 Elsevier Ltd. All rights reserved.	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	http://archimer.ifremer.fr/doc/00017/12811/11295.pdf

DOI:10.1016/j.envpol.2010.08.021	
Editor: 	Elsevier Sci Ltd	
Relação: 	http://archimer.ifremer.fr/doc/00017/12811/	
Formato: 	application/pdf	
Fonte: 	Environmental Pollution (0269-7491) (Elsevier Sci Ltd), 2010-12 , Vol. 158 , N. 12 , P. 3527-3533	
Fonte: 	2010 Elsevier Ltd All rights reserved.