Data/hora: 09/06/2024 07:49:02

Provedor de dados: | 5
País: | France
Título: | Fucoidan a sulfated polysaccharide from brown algae is a potent modulator of connective tissue proteolysis
Autores: | Senni, Karim; Gueniche, Farida; Foucault Bertaud, Alexandrine; Igondjo Tchen, Sylvie; Fioretti, Florence; Colliec-jouault, Sylvia; Durand, Patrick; Guezennec, Jean; Godeau, Gaston; Letourneur, Didier.
Data: | 2006
Ano: | 2006
Palavras-chave: | Interleukin 1 beta; Leukocyte elastase; Matrix metalloproteinases; Extracellular matrix remodeling; Glycosaminoglycans; Fucoidan.
Resumo: | Fucoidans are sulfated fucosylated polymers from brown algae cell wall that exhibit some heparin/heparan sulfate properties. We previously demonstrated that these polysaccharides were able in vitro to stimulate dermal fibroblast proliferation and extracellular matrix deposition. Here, we investigated the action of a 16 kDa fucoidan fraction on parameters involved in connective tissue breakdown. This fucoidan is able to inhibit gelatinase A secretion and stromelysin 1 induction by interleukin-1 beta on dermal fibroblasts in culture. Furthermore, we observed that fucoidan increases the rate of association of MMPs with their specific inhibitors namely TIMPs. Using tissue sections of human skin in ex vivo experiments, we evidenced that this polysaccharide was able to minimize human leukocyte elastase activity resulting in the protection of human skin elastic fiber network against the enzymatic proteolysis due to this serine proteinase. These results suggested that fucoidan could be used for treating some inflammatory pathologies in which uncontrolled extracellular matrix degradation takes place. (c) 2005 Elsevier Inc. All rights reserved.
Tipo: | Text
Idioma: | Inglês

Identificador:

http://archimer.ifremer.fr/doc/2006/publication-2147.pdf

DOI:10.1016/j.abb.2005.11.001

Editor: | Elsevier
Relação: | http://archimer.ifremer.fr/doc/00000/2147/
Formato: | application/pdf
Fonte: | Archives of Biochemistry and Biophysics (0003-9861) (Elsevier), 2006 , Vol. 445 , N. 1 , P. 56-64
Fonte: | 2006 Elsevier