Data/hora: 03/06/2024 03:28:33

Provedor de dados: | 5
País: | France
Título: | Msxb is a core component of the genetic circuitry specifying the dorsal and ventral neurogenic midlines in the ascidian embryo
Autores: | Roure, Agnes; Darras, Sebastien.
Data: | 2016-01
Ano: | 2016
Palavras-chave: | Ascidian; Gene regulatory network; Transcription factors; Peripheral nervous system; Neurogenic.
Resumo: | The tail ascidian larval peripheral nervous system is made up of epidermal sensory neurons distributed more or less regularly in ventral and dorsal midlines. Their formation occurs in two-steps: the ventral and dorsal midlines are induced as neurogenic territories by Fgf9/-16/20 and Admp respectively. The Delta2/Notch interaction,then controls the number of neurons that form. The genetic machinery acting between the inductive processes taking place before gastrulation and neuron specification at tailbud stages are largely unknown. The analysis of seven transcription factors expressed in the forming midlines revealed an unexpected complexity and dynamic of gene expression. Their systematic overexpression confirmed that these genes do not interact following a linear cascade of activation. However, the integration of our data revealed the distinct key roles of the two upstream factors Msxb and Nkx-C that are the earliest expressed genes and the only ones able to induce neurogenic midline and ESN formation. Our data suggest that Msxb would be the primary midline gene integrating inputs from the ventral and dorsal inducers and launching a pan-midline transcriptional program. Nkx-C would be involved in tail tip specification, in maintenance of the pan-midline network and in a posterior to anterior wave controlling differentiation.
Tipo: | Text
Idioma: | Inglês

Identificador:

https://archimer.ifremer.fr/doc/00374/48557/48984.pdf

https://archimer.ifremer.fr/doc/00374/48557/48985.pdf

https://archimer.ifremer.fr/doc/00374/48557/48986.pdf

https://archimer.ifremer.fr/doc/00374/48557/48987.pdf

https://archimer.ifremer.fr/doc/00374/48557/48988.pdf

https://archimer.ifremer.fr/doc/00374/48557/48989.pdf

https://archimer.ifremer.fr/doc/00374/48557/48990.pdf

https://archimer.ifremer.fr/doc/00374/48557/48991.pdf

DOI:10.1016/j.ydbio.2015.11.009

https://archimer.ifremer.fr/doc/00374/48557/

Editor: | Academic Press Inc Elsevier Science
Formato: | application/pdf
Fonte: | Developmental Biology (0012-1606) (Academic Press Inc Elsevier Science), 2016-01 , Vol. 409 , N. 1 , P. 277-287

Fonte:

2015 Published by Elsevier Inc.

info:eu-repo/semantics/openAccess

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