Data/hora: 07/06/2024 02:41:11

Provedor de dados: 	5	
País: 	France	
Título: 	Norwalk virus-specific binding to oyster digestive tissues	
Autores: 	Le Guyader, Soizick; Loisy, Fabienne; Atmar, R; Hutson, A; Estes, M; Ruvoen-clouet, N; Pommepuy, Monique; Le Pendu, J.	
Data: 	2006-06	
Ano: 	2006	
Palavras-chave: 	Bioaccumulation; Shellfish; Escherichia coli; Pathogen; Oyster digestive tissue; Noroviruses.	
Resumo: 	The primary pathogens related to shellfishborne gastroenteritis outbreaks are noroviruses. These viruses show persistence in oysters, which suggests an active mechanism of virus concentration. We investigated whether Norwalk virus or viruslike particles bind specifically to oyster tissues after bioaccumulation or addition to tissue sections. Since noroviruses attach to carbohydrates of the histo-blood group family, tests using immunohistochemical analysis were performed to evaluate specific binding of virus or viruslike particles to oyster tissues through these ligands. Viral particles bind specifically to digestive ducts (midgut, main and secondary ducts, and tubules) by carbohydrate structures with a terminal N-acetylgalactosamine residue in an alpha linkage (same binding site used for recognition of human histo-blood group antigens). These data show that the oyster can selectively concentrate a human pathogen and that conventional depuration will not eliminate noroviruses from oyster tissue.	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	http://archimer.ifremer.fr/doc/2006/publication-1542.pdf	
Editor: 	CDC	
Relação: 	http://archimer.ifremer.fr/doc/00000/1542/	
Formato: 	application/pdf	
Fonte: 	Emerging infectious diseases (1080-6040) (CDC), 2006-06 , Vol. 12 , N. 6 , P. 931-936	
Fonte: 	2006 the Centers for Disease Control and Prevention