Data/hora: 08/06/2024 09:23:27

Provedor de dados: | 5
País: | France
Título: | Floridoside extracted from the red alga Mastocarpus stellatus is a potent activator of the classical complement pathway
Autores: | Courtois, Anthony; Simon-colin, Christelle; Boisset, Claire; Berthou, Christian; Deslandes, Eric; Guezennec, Jean; Bordron, Anne.
Data: | 2008-09
Ano: | 2008
Palavras-chave: | Complement system; Immunomodulation; Marine algae; Alpha galactosyl glycerol.
Resumo: | Many biological properties of algae have been found to have useful applications in human health, particularly in the fields of oncology and immunology. Floridoside, extracted from the red alga Mastocarpus stellatus, has a structure similar to the xenoantigen Gal alpha 1-3 Gal. This xenoantigen has been described to induce a high immune response in human xenografts and is mediated by natural anti-gal antibodies that activate the classical complement pathway. Based on this property, we analyzed the potential activities of floridoside on the immune system. We demonstrated that floridoside activates a complement cascade via the classical complement pathway, through the recruitment and activation of natural IgM. This algal molecule could represent an important step in the development of a potent new anticomplementary agent for use in therapeutic complement depletion.
Tipo: | Text
Idioma: | Inglês

Identificador:

http://archimer.ifremer.fr/doc/2008/publication-6248.pdf

DOI:10.3390/md20080019

Editor: | Molecular Diversity Preservation International
Relação: | http://archimer.ifremer.fr/doc/00000/6248/
Formato: | application/pdf
Fonte: | Marine drugs (1660-3397) (Molecular Diversity Preservation International), 2008-09 , Vol. 6 , N. 3 , P. 407-417
Fonte: | 2008 Molecular Diversity Preservation International